Cannabinoids and Pain

Cannabinoids and neuropathic pain.

After a brief overview of the endocannabinoid system (CB receptors, and endocannabinoids) and of the cannabinergic ligands, some general issues related to cannabinoids and pain are commented. Finally, the most important findings regarding cannabinoids and neuropathic pain are discussed in detail.

Cannabinoids and Neuropathic Pain

Cannabinoids and pain

DOI 0.1093/bjacepd/mkg175 Cannabinoids have been used in medicine for many thousands of years, although use in Western medicine declined over the last century as more effective agents were discovered. The identification of an endogenous cannabinoid system, akin to the opioid system, has rekindled interest in cannabinoids as potential analgesic agents. Combined with growing scientific knowledge ...

Cannabinoids for Postoperative Pain

To the Editor:—An article published by Holdcroft et al. in the May 2006 issue of ANESTHESIOLOGY reported the analgesic and adverse effects of an oral cannabis extract for postoperative pain management. To date, only three other manuscripts investigating the role of cannabinoids in postoperative pain have been published. The conclusions from these studies are that cannabinoids are not ideally su...

Cannabinoids in cancer pain

This article of the month presents results of a clinical study conducted in the UK and Romania, which evaluated the efficacy of a THC:CBD cannabis extract (Sativex®) and a THC cannabis extract in the treatment of 177 patients with cancer pain, who experienced inadequate pain reduction despite intake of opioids [Johnson et al. J Pain Symptom Manage, 2010, in press]. Sativex resulted in a signifi...